Matanuska-Susitna College is accredited through the University of Alaska Anchorage and the Northwest Commission on Colleges and Universities (NWCCU).

The Alaska State Approving Agency for veteran’s educational benefits approves many programs of study at Mat-Su College.

As a unit of a statewide university system, the College benefits from the University of Alaska's membership in the Association of American State Colleges and Universities, the Association of State Universities and Land-Grant Colleges, and institutional membership in the American Council of Education, the American Association of Colleges for Teacher Education, and the Western Interstate Commission for Higher Education.

The University of Alaska is on the approved list of colleges and universities of the American Association of University Women.